Журналы Онкология. Журнал им. Герцена 1, Хирургический этап лечения в комплекс Хирургический этап лечения в комплексной терапии у больных генерализованным раком молочной железы Авторы: Редакция. Журнал: Онкология. Просмотрено: Скачано:
Targeting Hyaluronic Acid Family for Cancer Chemoprevention and Therapy
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Search tips: Search terms are case-insensitive Common words are ignored By default articles containing any term in the query are returned i. Hint: Quoting Chinese or Japanese words will help you to find exact word matches in mixed-language fields, e. Use parentheses to create more complex queries; e. Show more Hide breast cancer ovarian cancer 35 cancer of the cervix uteri 18 chemotherapy 14 endometrial cancer 14 cervical cancer 13 diagnosis 12 magnetic resonance imaging 11 radiotherapy 11 treatment 11 mammography 10 breast 9 human papillomavirus 9 laparoscopy 9 neoadjuvant chemotherapy 9. Show more Hide 41 19 26 23
Breast cancer BC is one of the most urgent as medical and social problems. In Ukraine, from to the present time, BC occupies the first rank in the structure of cancer morbidity and mortality among women. In the analysis of the incidence of BC, there are two age spikes: the first peak is 40—45 years premenopausal BC , the second — after 50—65 years postmenopausal BC.
Hyaluronic acid or hyaluronan HA is perhaps one of the most uncomplicated large polymers that regulates several normal physiological processes and, at the same time, contributes to the manifestation of a variety of chronic and acute diseases, including cancer. Members of the HA signaling pathway HA synthases, HA receptors, and HYAL-1 hyaluronidase have been experimentally shown to promote tumor growth, metastasis, and angiogenesis, and hence each of them is a potential target for cancer therapy. Furthermore, as these members are also overexpressed in a variety of carcinomas, targeting of the HA family is clinically relevant.